[HTML][HTML] Diagnostic performance of the molecular BCR-ABL1 monitoring system may impact on inclusion of CML patients in stopping trials

B Spiess, S Rinaldetti, N Naumann, N Galuschek… - PLoS …, 2019 - journals.plos.org
… Standardization and quality control studies of 'real-time' quantitative reverse transcriptase
polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia

Standardization of molecular monitoring for chronic myeloid leukemia: 2021 update

M Salmon, HE White, NCP Cross… - … Myeloid Leukemia, 2021 - Springer
… by reverse transcriptase polymerase chain reaction (RT-PCR) were initiated more than 30
… in complete cytogenetic remission (CCyR) on interferon alpha [7,8,9,10,11,12]. Competitive

[HTML][HTML] Chronic myeloid leukemia prognosis and therapy: criticisms and perspectives

D Russo, JV Garcia-Gutierrez, S Soverini… - Journal of Clinical …, 2020 - mdpi.com
… (allo-SCT) and interferon-alpha (IFNα) have been proven to … transcription polymerase chain
reaction (RT-qPCR) [6,7,8]. … Preservation of quiescent chronic myelogenous leukemia stem …

How we monitor the therapy effectiveness in patients with chronic myeloid leukemia-A Single center experience

S Mešanović, A Žugić-Jahić, S Hasić, V Simendić… - Genetics & …, 2023 - genapp.ba
… The quantitative real-time polymerase chain reaction method (… adherence in chronic
myelogenous leukemia in the chronic … after failure of interferon-alpha treatment. Blood 1;111(3):…

Chronic myeloid leukemia: 2020 update on diagnosis, therapy and monitoring

E Jabbour, H Kantarjian - American journal of hematology, 2020 - Wiley Online Library
… Baseline reverse transcriptase-polymerase chain reaction is … It acts via competitive inhibition
at the ATP-binding site of the … Given the equivalent efficacy and lower toxicity of lower dose …

[HTML][HTML] Treatment-Free Remission—A New Aim in the Treatment of Chronic Myeloid Leukemia

P Kwaśnik, K Giannopoulos - Journal of Personalized Medicine, 2021 - mdpi.com
… The role of modern droplet digital polymerase chain reaction (… to the treatment of TKI, then
interferon alpha (IFN-α) therapy is … to the patient allows for careful monitoring of the patient. …

Human leukocyte antigen-B phenotype and minimal residual disease in chronic myeloid leukemia patients treated with imatinib: Is there an association?

E Hadad, A Ehsanpour, T Vosoughi… - Clinical Cancer …, 2020 - search.ebscohost.com
… ) in chronic myelogenous leukemia (CML) patients treated … by real‑time polymerase chain
reaction technique. Results: No … of the drugs used to treat cancer such as interferonalpha (…

[PDF][PDF] Chronic Myeloid Leukemia: Epidemiology, Diagnosis, Evaluation and Monitoring

S Abdul-Rahman, GA Hamid - researchgate.net
… The polymerase chain reaction (PCR) is one of the most … the survival of CML patients treated
with interferon-alpha –based … abnormality in chronic myelogenous leukaemia identified by …

Dasatinib plus Peg‐Interferon alpha 2b combination in newly diagnosed chronic phase chronic myeloid leukaemia: Results of a multicenter phase 2 study (DASA …

…, F Guilhot, French CML Group (FiLMC) - British Journal of …, 2023 - Wiley Online Library
… real-time quantitative polymerase chain reaction analysis on … for potential competing events
unrelated to CML or therapy. In … Finally, using an initial monitoring of the dose of dasatinib, …

The Interferon-Alpha Revival in CML

M Talpaz, J Mercer, R Hehlmann - Chronic Myeloid Leukemia, 2021 - Springer
… wild-type cells in competitive repopulation assays [36]. … in monitoring or even predicting
response to IFNα therapy. … improve adherence to treatment without reducing efficacy, and …